2-Deoxy-D-glucose (2-DG), >98% (5g)

Description

2-Deoxy-D-glucose (2-DG, 2DG), >98% (5g)

SYNONYMS:2-Deoxy-D-arabinohexose
PURITY LIMIT:≥ 98% (HPLC Assay)
MOLECULAR FORMULA: C6H12O5
MOLECULAR WEIGHT:164.16
CAS NO:154-17-6
MDL NO: MFCD00151328
APPEARANCE: White to almost white powder
OPTICAL ROTATION: +45.0° to +47.5°
STORAGE TEMP:Store at Room Temperature. It is fine to freeze.
solubility water: 5 mg/mL

2-Deoxy-D-glucose (2-DG) is a non-metabolizable derivative of glucose that can be carried by the glucose carrier in human cells. 2-Deoxy-D-Glucose (2-Deoxyglucose) is a glucose analog that inhibits glycolysis via its actions on hexokinase, the rate limiting step of glycolysis. It is phosphorylated by hexokinase to 2-DG-P which can not be further metabolized by phosphoglucose isomerase. This leads to the accumulation of 2-DG-P in the cell and the depletion in cellular ATP. Reported to reduce the incidence of doxorubicin-induced apoptosis. 2-Deoxy-D-glucose (2-DG) is used in glucoprivic feeding research to invoke and study the processes of counter-regulatory response (CRR). 2-Deoxy-D-glucose is used in the development of anti-cancer strategies that involve radio- and chemosensitization and oxidative stress.

In vitro, 2-Deoxyglucose has been shown to induce autophagy, increase ROS production, and activate AMPK.

References:

Moleculin Announces Active Compound in WP1122 Reduces Coronavirus Replication In Vitro by 100%
https://www.ptcommunity.com/wire/moleculin-announces-active-compound-wp1122-reduces-coronavirus-replication-vitro-100

https://www.prnewswire.com/news-releases/moleculin-announces-active-compound-in-wp1122-reduces-coronavirus-replication-in-vitro-by-100-301037143.html