Tenofovir disoproxil fumarate (10g) (TDF-10g)

Description

Tenofovir disoproxil fumarate (tenofovir DF) is a type of anti-HIV medicine called a nucleoside reverse transcriptase inhibitor (NRTI).
MDL number MFCD00952920
Cas Number : 201341-05-1
Molecular Weight : 519.4400

Tenofovir disoproxil is a medication used to treat chronic hepatitis B and to prevent and treat HIV/AIDS. It may be used for prevention of HIV/AIDS among those at high risk before exposure, and after a needlestick injury or other potential exposure. It is sold both by itself and together as emtricitabine/tenofovir and efavirenz/emtricitabine/tenofovir.

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[2] W.R. Zhang, R. Scherzer, M.M. Estrella, S.B. Ascher, A. Muiru, V. Jotwani, C. Grunfeld, C.R. Parikh, D. Gustafson, S. Kassaye, A. Sharma, M. Cohen, P.C. Tien, D.K. Ng, F.J. Palella, Jr., M.D. Witt, K. Ho, M.G. Shlipak, Tenofovir disoproxil fumarate initiation and changes in urinary biomarker concentrations among HIV-infected men and women, AIDS 33(4) (2019) 723-733.

[3] S. Noe, S. Heldwein, H. Jaeger, M. Page, E. Wolf, Tenofovir disoproxil fumarate/emtricitabine is associated with a higher risk of hypocalcemia compared to abacavir/lamivudine – results from a German cohort study, Int J STD AIDS 30(5) (2019) 447-452.

[4] M. Lu, H. Dong, D. Bao, B. Liu, H. Liu, Tenofovir disoproxil fumarate induces pheochromocytoma cells apoptosis, Eur J Pharmacol 844 (2019) 139-144.

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[8] R. Guner, Z. Kocak Tufan, G.R. Yilmaz, A.T. Mehmet, Tenofovir disoproxil fumarate may not cause renal and bone toxicity in chronic hepatitis B patients: a retrospective cross-sectional study, Turk J Med Sci 49(1) (2019) 451-452.

[9] J.A. Fields, M.K. Swinton, A. Carson, B. Soontornniyomkij, C. Lindsay, M.M. Han, K. Frizzi, S. Sambhwani, A. Murphy, C.L. Achim, R.J. Ellis, N.A. Calcutt, Tenofovir disoproxil fumarate induces peripheral neuropathy and alters inflammation and mitochondrial biogenesis in the brains of mice, Sci Rep 9(1) (2019) 17158.

[10] J. Cusato, A. Calcagno, A. De Nicolo, K. Mogyorosi, A. D’Avolio, G. Di Perri, S. Bonora, Tenofovir Alafenamide and Tenofovir Disoproxil Fumarate are not transported by Concentrative Nucleoside Transporter 2, Diagn Microbiol Infect Dis 94(2) (2019) 202-204.

[11] A. Calcagno, M. Fiumano, D. Zugna, J. Cusato, C. Montrucchio, L. Marinaro, L. Trentini, M. Ferrara, A. D’Avolio, C. Pizzi, G. Di Perri, S. Bonora, Tenofovir disoproxil fumarate discontinuation for renal outcomes: any room for treatment personalization?, Pharmacogenomics J 19(1) (2019) 65-71.

[12] P. Zhang, Q. Liu, M. Yuan, L. Wang, Tenofovir disoproxil fumarate reduce incidence of HCC development in CHB-patients with compensated cirrhosis, Infect Agent Cancer 13 (2018) 30.

[13] R.R. Patel, R. Presti, L.C. Harrison, W.G. Powderly, P.A. Chan, Tenofovir disoproxil fumarate as pre-exposure prophylaxis for HIV prevention in women with osteoporosis: a case report and review of the literature, Antivir Ther 23(4) (2018) 379-382.

[14] S. Noe, S. Heldwein, C. Wiese, R. Pascucci, A. von Krosigk, F. Schabaz, C. Jonsson-Oldenbuettel, H. Jaeger, E. Wolf, Tenofovir Disoproxil Fumarate Is Associated with a Set-Point Variation in the Calcium-Parathyroid Hormone-Vitamin D Axis: Results from a German Cohort, Adv Pharmacol Sci 2018 (2018) 6069131.

[15] D. Mizushima, D.T.H. Nguyen, D.T. Nguyen, S. Matsumoto, J. Tanuma, H. Gatanaga, N.V. Trung, N. van Kinh, S. Oka, Tenofovir disoproxil fumarate co-administered with lopinavir/ritonavir is strongly associated with tubular damage and chronic kidney disease, J Infect Chemother 24(7) (2018) 549-554.

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[18] M.K. Kang, J.G. Park, Tenofovir disoproxil fumarate-induced severe liver injury in a patient with chronic hepatitis B virus infection, Dig Liver Dis 50(6) (2018) 628-630.

[19] A. Hill, S.L. Hughes, D. Gotham, A.L. Pozniak, Tenofovir alafenamide versus tenofovir disoproxil fumarate: is there a true difference in efficacy and safety?, J Virus Erad 4(2) (2018) 72-79.

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[22] W. Tun-Yhong, C. Chinpaisal, P. Pamonsinlapatham, S. Kaewkitichai, Tenofovir Disoproxil Fumarate Is a New Substrate of ATP-Binding Cassette Subfamily C Member 11, Antimicrob Agents Chemother 61(4) (2017).

[23] H. Shen, W. Li, W.G. Humphreys, Y. Lai, Tenofovir Disoproxil Fumarate Is Not an Inhibitor of Human Organic Cation Transporter 1, J Pharmacol Exp Ther 360(2) (2017) 341-342.

[24] J. Shailender, P.R. Ravi, P. Saha, A. Dalvi, S. Myneni, Tenofovir disoproxil fumarate loaded PLGA nanoparticles for enhanced oral absorption: Effect of experimental variables and in vitro, ex vivo and in vivo evaluation, Colloids Surf B Biointerfaces 158 (2017) 610-619.

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[28] L.M. Mofenson, R.C. Baggaley, I. Mameletzis, Tenofovir disoproxil fumarate safety for women and their infants during pregnancy and breastfeeding, AIDS 31(2) (2017) 213-232.

[29] S. Khan, C.A. Funk, K. Corado, S. Morris, M.P. Dube, Tenofovir Disoproxil Fumarate-Associated Fanconi Syndrome in an Human Immunodeficiency Virus (HIV)-Uninfected Man Receiving HIV Pre-Exposure Prophylaxis, Open Forum Infect Dis 4(3) (2017) ofx149.

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[37] C.Y. Cheng, S.Y. Chang, M.H. Lin, S.Y. Ku, N.L. Sun, S.H. Cheng, Tenofovir disoproxil fumarate-associated hypophosphatemia as determined by fractional excretion of filtered phosphate in HIV-infected patients, J Infect Chemother 22(11) (2016) 744-747.

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